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2013
Baggelaar, M.P., Janssen, F.J., van Esbroeck, A.C.M., den Dulk, H., Allara, M., Hoogendoorn, S., McGuire, R., Florea, B. I, Meeuwenoord, N., van den Elst, H., van der Marel, G.A., Brouwer, J., Di Marzo, V., Overkleeft, H.S., van der Stelt, M. , Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-alpha in Brain, Angewandte Chemie-International Edition, vol. 52, no. 46, pp. 12081-12085. DOI
2012
Wennekes, T., Bonger, K.M., Vogel, K., van den Berg, R.J.B.H.N., Strijland, A., Donker-Koopman, W.E., Aerts, J.M.F.G., van der Marel, G.A., Overkleeft, H.S. , The Development of an Aza-C-Glycoside Library Based on a Tandem Staudinger/Aza-Wittig/Ugi Three-Component Reaction, European Journal of Organic Chemistry, no. 32, pp. 6420-6454.
Kallemeijn, W.W., Li, K.Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J.B., Willems, L. I, Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B. I, Codee, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12529-12533.
Walvoort, M.T.C., Kallemeijn, W.W., Willems, L. I, Witte, M.D., Aerts, J.M.F.G., van der Marel, G.A., Codee, J.D.C., Overkleeft, H.S. , Tuning the leaving group in 2-deoxy-2-fluoroglucoside results in improved activity-based retaining beta-glucosidase probes, Chemical Communications, vol. 48, no. 84, pp. 10386-10388.
2011
Willems, L. I, Van der Linden, W.A., Li, N., Li, K.Y., Liu, N., Hoogendoorn, S., Van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling, Accounts of Chemical Research, vol. 44, no. 9, pp. 718-729.
Clerc, J., Li, N., Krahn, D., Groll, M., Bachmann, A.S., Florea, B. I, Overkleeft, H.S., Kaiser, M. , The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity, Chem Commun (Camb), vol. 47, no. 1, pp. 385-7. DOI
2010
Geurink, P.P., Liu, N., Spaans, M.P., Downey, S.L., van den Nieuwendijk, A., van der Marel, G.A., Kisselev, A.F., Florea, B. I, Overkleeft, H.S. , Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome's Chymotrypsin-like Sites, Journal of Medicinal Chemistry, vol. 53, no. 5, pp. 2319-2323. DOI
Wennekes, T., van den Berg, R., Boltje, T.J., Donker-Koopman, W.E., Kuijper, B., van der Marel, G.A., Strijland, A., Verhagen, C.P., Aerts, J., Overkleeft, H.S. , Synthesis and Evaluation of Lipophilic Aza-C-glycosides as Inhibitors of Glucosylceramide Metabolism, European Journal of Organic Chemistry, no. 7, pp. 1258-1283. DOI
van Scherpenzeel, M., van den Berg, R., Donker-Koopman, W.E., Liskamp, R.M.J., Aerts, J., Overkleeft, H.S., Pieters, R.J. , Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase, Bioorganic & Medicinal Chemistry, vol. 18, no. 1, pp. 267-273. DOI
2009
Witte, M.D., Florea, B. I, Verdoes, M., Adeyanju, O., Van der Marel, G.A., Overkleeft, H.S. , O-GlcNAc Peptide Epoxyketones Are Recognized by Mammalian Proteasomes, Journal of the American Chemical Society, vol. 131, no. 34, pp. 12064-+. DOI
Clerc, J., Florea, B. I, Kraus, M., Groll, M., Huber, R., Bachmann, A.S., Dudler, R., Driessen, C., Overkleeft, H.S., Kaiser, M. , Syringolin A Selectively Labels the 20 S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines, Chembiochem, vol. 10, no. 16, pp. 2638-2643. DOI
Ruckrich, T., Kraus, M., Gogel, J., Beck, A., Ovaa, H., Verdoes, M., Overkleeft, H.S., Kalbacher, H., Driessen, C. , Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells, Leukemia, vol. 23, no. 6, pp. 1098-1105. DOI
Verdoes, M., Florea, B. I, van der Marel, G.A., Overkleeft, H.S. , Chemical Tools To Study the Proteasome, European Journal of Organic Chemistry, no. 20, pp. 3301-3313. DOI
Klein, T., Geurink, P.P., Overkleeft, H.S., Kauffman, H.K., Bischoff, R. , Functional Proteomics on Zinc-Dependent Metalloproteinases using Inhibitor Probes, Chemmedchem, vol. 4, no. 2, pp. 164-170. DOI
Risseeuw, M.D.P., van den Berg, R., Donker-Koopman, W.E., van der Marel, G.A., Aerts, J., Overhand, M., Overkleeft, H.S. , Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors, Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 23, pp. 6600-6603. DOI
Geurink, P., Klein, T., Leeuwenburgh, M., van der Marel, G., Kauffman, H., Bischoff, R., Overkleeft, H. , A peptide hydroxamate library for enrichment of metalloproteinases: towards an affinity-based metalloproteinase profiling protocol, Org Biomol Chem, vol. 6, no. 7, pp. 1244-50. DOI
Wennekes, T., van den Berg, R., Boot, R.G., van der Marel, G.A., Overkleeft, H.S., Aerts, J. , Glycosphingolipids-Nature, Function, and Pharmacological Modulation, Angewandte Chemie-International Edition, vol. 48, no. 47, pp. 8848-8869. DOI
2008
Kuijl, C., Tuin, A.W., Overkleeft, H., Neefjes, J. , Reciprocal chemical genetics for swift lead and target identification, Molecular Biosystems, vol. 4, no. 10, pp. 1001-1008. DOI
Verdoes, M., Florea, B. I, Hillaert, W., Willems, L. I, van der Linden, W.A., Sae-Heng, M., Filippov, D.V., Kisseley, A.F., van der Marel, G.A., Overkleeft, H.S. , Azido-BODIPY acid reveals quantitative Staudinger-Bertozzi ligation in two-step activity-based proteasome profiling, Chembiochem, vol. 9, no. 11, pp. 1735-1738. DOI
Kraus, M., Malenke, E., Gogel, J., Muller, H., Ruckrich, T., Overkleeft, H., Ovaa, H., Koscielniak, E., Hartmann, J.T., Driessen, C. , Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis, Molecular Cancer Therapeutics, vol. 7, no. 7, pp. 1940-1948. DOI
Geurink, P., Klein, T., Leeuwenburgh, M., van der Marel, G., Kauffman, H., Bischoff, R., Overkleeft, H. , A peptide hydroxamate library for enrichment of metalloproteinases: towards an affinity-based metalloproteinase profiling protocol, Organic & Biomolecular Chemistry, vol. 6, no. 7, pp. 1244-1250. DOI
2007
Risseeuw, M.D.P., Overhand, M., Fleet, G.W.J., Simone, M. I , A compendium of sugar amino acids (SAA): scaffolds, peptide- and glyco-mimetics, Tetrahedron-Asymmetry, vol. 18, no. 17, pp. 2001-2010. DOI
van Swieten, P.F., Samuel, E., Hernandez, R.O., van den Nieuwendijk, A.M.C.H., Leeuwenburgh, M.A., van der Marel, G.A., Kessler, B.M., Overkleeft, H.S., Kisselev, A.F. , A cell-permeable inhilbitor and activity-based probe for the caspase-like activity of the proteasome, Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 12, pp. 3402-3405. DOI
Rohrig, C.H., Loch, C., Guan, J.Y., Siegal, G., Overhand, M. , Fragment-based synthesis and SAR of modified FKBP ligands: Influence of different linking on binding affinity, Chemmedchem, vol. 2, no. 7, pp. 1054-1070. DOI
Kraus, M., Ruckrich, T., Reich, M., Gogel, J., Beck, A., Kammer, W., Berkers, C.R., Burg, D., Overkleeft, H., Ovaa, H., Driessen, C. , Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells, Leukemia, vol. 21, no. 1, pp. 84-92.