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2014
Engelsma, S.B., Willems, L. I, van Paaschen, C.E., van Kasteren, S. I, van der Marel, G.A., Overkleeft, H.S., Filippov, D.V. , Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels-Alder Ligation, Organic Letters, vol. 16, no. 10, pp. 2744-2747. DOI
Ferraz, M.J., Kallemeijn, W.W., Mirzaian, M., Herrera Moro, D., Marques, A., Wisse, P., Boot, R.G., Willems, L. I, Overkleeft, H.S., Aerts, J.M. , Gaucher disease and Fabry disease: new markers and insights in pathophysiology for two distinct glycosphingolipidoses, Biochimica et biophysica acta, vol. 1841, no. 5, pp. 811-25. DOI
Willems, M.M.J.H.P., Zom, G.G., Meeuwenoord, N., Ossendorp, F.A., Overkleeft, H.S., van der Marel, G.A., Codee, J.D.C., Filippov, D.V. , Design, automated synthesis and immunological evaluation of NOD2-ligand-antigen conjugates, Beilstein Journal of Organic Chemistry, vol. 10, pp. 1445-1453. DOI
Willems, M.M., Zom, G.G., Khan, S., Meeuwenoord, N., Melief, C.J., van der Stelt, M., Overkleeft, H.S., Codee, J.D., van der Marel, G.A., Ossendorp, F., Filippov, D.V. , N-Tetradecylcarbamyl Lipopeptides as Novel Agonists for Toll-like Receptor 2, Journal of Medicinal Chemistry. DOI
Willems, L. I, Overkleeft, H.S., van Kasteren, S. I , Current developments in activity-based protein profiling, Bioconjugate chemistry, vol. 25, no. 7, pp. 1181-91. DOI
2013
Li, N., Kuo, C.L., Paniagua, G., van den Elst, H., Verdoes, M., Willems, L. I, van der Linden, W.A., Ruben, M., van Genderen, E., Gubbens, J., van Wezel, G.P., Overkleeft, H.S., Florea, B. I , Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS, Nature Protocols, vol. 8, no. 6, pp. 1155-68. DOI
2012
van der Linden, W.A., Willems, L. I, Shabaneh, T.B., Li, N., Ruben, M., Florea, B. I, van der Marel, G.A., Kaiser, M., Kisselev, A.F., Overkleeft, H.S. , Discovery of a potent and highly beta 1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones, Organic & Biomolecular Chemistry, vol. 10, no. 1, pp. 181-194. DOI
Willems, L. I, Li, N., Florea, B. I, Ruben, M., van der Marel, G.A., Overkleeft, H.S. , Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities, Angewandte Chemie-International Edition, vol. 51, no. 18, pp. 4431-4434. DOI
Kallemeijn, W.W., Li, K.Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J.B., Willems, L. I, Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B. I, Codee, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12529-12533.
Walvoort, M.T.C., Kallemeijn, W.W., Willems, L. I, Witte, M.D., Aerts, J.M.F.G., van der Marel, G.A., Codee, J.D.C., Overkleeft, H.S. , Tuning the leaving group in 2-deoxy-2-fluoroglucoside results in improved activity-based retaining beta-glucosidase probes, Chemical Communications, vol. 48, no. 84, pp. 10386-10388.
2011
Willems, L. I, Van der Linden, W.A., Li, N., Li, K.Y., Liu, N., Hoogendoorn, S., Van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling, Accounts of Chemical Research, vol. 44, no. 9, pp. 718-729.
Hoogendoorn, S., Blom, A.E.M., Willems, L. I, van der Marel, G.A., Overkleeft, H.S. , Synthesis of pH-Activatable Red Fluorescent BODIPY Dyes with Distinct Functionalities, Organic Letters, vol. 13, no. 20, pp. 5656-5659.
Hoogendoorn, S., Willems, L., Florea, B., Overkleeft, H. , Hypersensitive Response to Over-reactive Cysteines, Angew Chem Int Ed Engl, vol. 50, issue 24, pp. 5434-5436. DOI
Kolodziejek, I, Misas-Villamil, J.C., Kaschani, F., Clerc, J., Gu, C., Krahn, D., Niessen, S., Verdoes, M., Willems, L. I, Overkleeft, H.S., Kaiser, M., van der Hoorn, R.A. , Proteasome activity imaging and profiling characterizes bacterial effector syringolin A, Plant Physiol, vol. 155, no. 1, pp. 477-89. DOI
2010
Verdoes, M., Willems, L. I, van der Linden, W.A., Duivenvoorden, B.A., van der Marel, G.A., Florea, B. I, Kisselev, A.F., Overkleeft, H.S. , A panel of subunit-selective activity-based proteasome probes, Org Biomol Chem, vol. 8, pp. 2719-2727. DOI
Willems, L. I, Verdoes, M., Florea, B. I, van der Marel, G.A., Overkleeft, H.S. , Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation, ChemBioChem, vol. 11, pp. 1769-1781.
2008
Verdoes, M., Florea, B. I, Hillaert, W., Willems, L. I, van der Linden, W.A., Sae-Heng, M., Filippov, D.V., Kisseley, A.F., van der Marel, G.A., Overkleeft, H.S. , Azido-BODIPY acid reveals quantitative Staudinger-Bertozzi ligation in two-step activity-based proteasome profiling, Chembiochem, vol. 9, no. 11, pp. 1735-1738. DOI
1997
vanDongen, M.J.P., Mooren, M.M.W., Willems, E.F.A., vanderMarel, G.A., vanBoom, J.H., Wijmenga, S.S., Hilbers, C.W. , Structural features of the DNA hairpin d(ATCCTA-GTTA-TAGGAT): Formation of a G-A base pair in the loop, Nucleic Acids Research, vol. 25, no. 8, pp. 1537-1547.
1992
Zandbergen, P., Willems, H.M.G., Vandermarel, G.A., Brussee, J., Vandergen, A. , 2-Phenoxypropene as Protective Reagent of Chiral Alcohols, Synthetic Communications, vol. 22, no. 19, pp. 2781-2787.