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Lombardo, E., van Roomen, C.P.A.A., van Puijvelde, G.H., Ottenhoff, R., van Eijk, M., Aten, J., Kuiper, J., Overkleeft, H.S., Groen, A.K., Verhoeven, A.J., Aerts, J.M.F.G., Bietrix, F. , Correction of Liver Steatosis by a Hydrophobic Iminosugar Modulating Glycosphingolipids Metabolism, Plos One, vol. 7, no. 10.
Vrins, C.L.J., Bietrix, F., Lombardo, E., van Roomen, C.P.P.A., Ottenhoff, R., Overkleeft, H.S., Aerts, J.M. , Glycosphingolipid synthesis inhibitor AMP-DNM lowers plasma cholesterol levels by promoting fecal cholesterol excretion without inhibiting cholesterol absorption, Clinical Lipidology, vol. 7, no. 2, pp. 241-248. DOI
Kallemeijn, W.W., Li, K.Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J.B., Willems, L. I, Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B. I, Codee, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12529-12533.
Aerts, J.M., Boot, R.G., van Eijk, M., Groener, J., Bijl, N., Lombardo, E., Bietrix, F.M., Dekker, N., Groen, A.K., Ottenhoff, R., van Roomen, C., Aten, J., Serlie, M., Langeveld, M., Wennekes, T., Overkleeft, H.S. , Glycosphingolipids and Insulin Resistance, Sphingolipids and Metabolic Disease, vol. 721, pp. 99-119.
Wennekes, T., Meijer, A.J., Groen, A.K., Boot, R.G., Groener, J.E., van Eijk, M., Ottenhoff, R., Bijl, N., Ghauharali, K., Song, H., O'Shea, T.J., Liu, H.L., Yew, N., Copeland, D., van den Berg, R.J., van der Marel, G.A., Overkleeft, H.S., Aerts, J.M. , Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation, Journal of Medicinal Chemistry, vol. 53, no. 2, pp. 689-698. DOI
Witte, M.D., Kallemeijn, W.W., Aten, J., Li, K.Y., Strijland, A., Donker-Koopman, W.E., van den Nieuwendijk, A., Bleijlevens, B., Kramer, G., Florea, B. I, Hooibrink, B., Hollak, C.E.M., Ottenhoff, R., Boot, R.G., van der Marel, G.A., Overkleeft, H.S., Aerts, J. , Ultrasensitive in situ visualization of active glucocerebrosidase molecules, Nature Chemical Biology, vol. 6, no. 12, pp. 907-913. DOI
van Eijk, M., Aten, J., Bijl, N., Ottenhoff, R., van Roomen, C.P.A.A., Dubbelhuis, P.F., Seeman, I, der Ghauharali-van Vlugt, K., Overkleeft, H.S., Arbeeny, C., Groen, A.K., Aerts, J.M.F.G. , Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation, PLoS ONE, vol. 4, no. 3, pp. 1-11. DOI
Kuijl, C., Savage, N.D.L., Marsman, M., Tuin, A.W., Janssen, L., Egan, D.A., Ketema, M., van den Nieuwendijk, R., van den Eeden, S.J.F., Geluk, A., Poot, A., van der Marel, G., Beijersbergen, R.L., Overkleeft, H., Ottenhoff, T.H.M., Neefjes, J. , Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1, Nature, vol. 450, no. 7170, pp. 725-U10. DOI
Aerts, J.M., Ottenhoff, R., Powlson, A.S., Grefhorst, A., van Eijk, M., Dubbelhuis, P.F., Aten, J., Kuipers, F., Serlie, M.J., Wennekes, T., Sethi, J.K., O'Rahilly, S., Overkleeft, H.S. , Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity, Diabetes, vol. 56, no. 5, pp. 1341-1349.
Kriek, N.M.A.J., van der Hout, E., Kelly, P., van Meijgaarden, K.E., Geluk, A., Ottenhoff, T.H.M., van der Marel, G.A., Overhand, M., van Boom, J.H., Valentijn, A.R.P.M., Overkleeft, H.S. , Synthesis of novel tetrahydropyran-based dipeptide isosters by Overman rearrangement of 2,3-didehydroglycosides, European Journal of Organic Chemistry, no. 13, pp. 2418-2427.