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Li, H., van der Linden, W.A., Verdoes, M., Florea, B. I, McAllister, F.E., Govindaswamy, K., Elias, J.E., Bhanot, P., Overkleeft, H.S., Bogyo, M. , Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes, ACS chemical biology. DOI
Li, N., Kuo, C.L., Paniagua, G., van den Elst, H., Verdoes, M., Willems, L. I, van der Linden, W.A., Ruben, M., van Genderen, E., Gubbens, J., van Wezel, G.P., Overkleeft, H.S., Florea, B. I , Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS, Nature Protocols, vol. 8, no. 6, pp. 1155-68. DOI
van der Linden, W.A., Li, N., Hoogendoorn, S., Ruben, M., Verdoes, M., Guo, J., Boons, G., van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: A comparative study, Bioorganic & Medicinal Chemistry, vol. 20, no. 2, pp. 662-666. DOI
Brouwer, A.J., Jonker, A., Werkhoven, P., Kuo, E., Li, N., Gallastegui, N., Kernmink, J., Florea, B. I, Groll, M., Overkleeft, H.S., Liskamp, R.M.J. , Peptido Sulfonyl Fluorides as New Powerful Proteasome Inhibitors, Journal of Medicinal Chemistry, vol. 55, no. 24, pp. 10995-11003. DOI
Stolze, S.C., Deu, E., Kaschani, F., Li, N., Florea, B. I, Richau, K.H., Colby, T., van der Hoom, R.A.L., Overkleeft, H.S., Bogyo, M., Kaiser, M. , The Antimalarial Natural Product Symplostatin 4 Is a Nanomolar Inhibitor of the Food Vacuole Falcipains, Chemistry & Biology, vol. 19, no. 12, pp. 1546-1555. DOI
Li, N., Overkleeft, H.S., Florea, B. I , Activity-based protein profiling: an enabling technology in chemical biology research, Current Opinion in Chemical Biology, vol. 16, no. 1-2, pp. 227-233. DOI
van der Linden, W.A., Willems, L. I, Shabaneh, T.B., Li, N., Ruben, M., Florea, B. I, van der Marel, G.A., Kaiser, M., Kisselev, A.F., Overkleeft, H.S. , Discovery of a potent and highly beta 1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones, Organic & Biomolecular Chemistry, vol. 10, no. 1, pp. 181-194. DOI
Janssen, K.G.H., Li, J., Hoang, H.T., Vulto, P., van den Berg, R.J.B.H.N., Overkleeft, H.S., Eijkel, J.C.T., Tas, N.R., van der Linden, H.J., Hankemeier, T. , Limits of miniaturization: Assessing ITP performance in sub-micron and nanochannels, Lab on a Chip, vol. 12, no. 16, pp. 2888-2893. DOI
Willems, L. I, Li, N., Florea, B. I, Ruben, M., van der Marel, G.A., Overkleeft, H.S. , Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities, Angewandte Chemie-International Edition, vol. 51, no. 18, pp. 4431-4434. DOI
Li, J., Girard, G., Florea, B. I, Geurink, P.P., Li, N., van der Marel, G.A., Overhand, M., Overkleeft, H.S., van Wezel, G.P. , Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach, Organic & Biomolecular Chemistry, vol. 10, no. 43, pp. 8677-8683.
Kallemeijn, W.W., Li, K.Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J.B., Willems, L. I, Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B. I, Codee, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12529-12533.
Willems, L. I, Van der Linden, W.A., Li, N., Li, K.Y., Liu, N., Hoogendoorn, S., Van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling, Accounts of Chemical Research, vol. 44, no. 9, pp. 718-729.
Witte, M.D., Walvoort, M.T., Li, K.Y., Kallemeijn, W.W., Donker-Koopman, W.E., Boot, R.G., Aerts, J.M., Codee, J.D., van der Marel, G.A., Overkleeft, H.S. , Activity-Based Profiling of Retaining beta-Glucosidases: A Comparative Study, Chembiochem, vol. 12, no. 8, pp. 1263-9. DOI
Clerc, J., Li, N., Krahn, D., Groll, M., Bachmann, A.S., Florea, B. I, Overkleeft, H.S., Kaiser, M. , The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity, Chem Commun (Camb), vol. 47, no. 1, pp. 385-7. DOI
Geurink, P.P., Florea, B. I, Li, N., Witte, M.D., Verasdonck, J., Kuo, C.L., van der Marel, G.A., Overkleeft, H.S. , A levulinoyl ester based cleavable linker for activity-based protein profiling, Angewandte Chemie, International Edition, pp. in press.
Florea, B. I, Verdoes, M., Li, N., van der Linden, W.A., Geurink, P.P., van den Elst, H., Hofmann, T., de Ru, A., van Veelen, P.A., Tanaka, K., Sasaki, K., Murata, S., den Dulk, H., Brouwer, J., Ossendorp, F.A., Kisselev, A.F., Overkleeft, H.S. , Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t, Chemistry & Biology, vol. 17, pp. 795-801.
Geurink, P.P., Florea, B. I, Li, N., Witte, M.D., Verasdonck, J., Kuo, C.L., van der Marel, G.A., Overkleeft, H.S. , A Cleavable Linker Based on the Levulinoyl Ester for Activity-Based Protein Profiling, Angewandte Chemie-International Edition, vol. 49, no. 38, pp. 6802-6805. DOI
Witte, M.D., Kallemeijn, W.W., Aten, J., Li, K.Y., Strijland, A., Donker-Koopman, W.E., van den Nieuwendijk, A., Bleijlevens, B., Kramer, G., Florea, B. I, Hooibrink, B., Hollak, C.E.M., Ottenhoff, R., Boot, R.G., van der Marel, G.A., Overkleeft, H.S., Aerts, J. , Ultrasensitive in situ visualization of active glucocerebrosidase molecules, Nature Chemical Biology, vol. 6, no. 12, pp. 907-913. DOI
Maynard, C.J., Bottcher, C., Ortega, Z., Smith, R., Florea, B. I, Diaz-Hernandez, M., Brundin, P., Overkleeft, H.S., Li, J.Y., Lucas, J.J., Dantuma, N.P. , Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment, Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 33, pp. 13986-13991. DOI
McCormick, J., Li, Y.B., McCormick, K., Duynstee, H. I, van Engen, A.K., van der Marel, G.A., Ganem, B., van Boom, J.H., Meinwald, J. , Structure and total synthesis of HF-7, a neuroactive glyconucleoside disulfate from the funnel-web spider Hololena curta, Journal of the American Chemical Society, vol. 121, no. 24, pp. 5661-5665.
Gao, Y.G., Liaw, Y.C., Li, Y.K., Vandermarel, G.A., Vanboom, J.H., Wang, A.H.J. , Facile Formation of a Cross-Linked Adduct between DNA and the Daunorubicin Derivative Mar70 Mediated by Formaldehyde - Molecular-Structure of the Mar70-D(Cgtnacg) Covalent Adduct, Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 11, pp. 4845-4849.