All journal publications (1963-2013)

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2012
van der Linden, W.A., Li, N., Hoogendoorn, S., Ruben, M., Verdoes, M., Guo, J., Boons, G., van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: A comparative study, Bioorganic & Medicinal Chemistry, vol. 20, no. 2, pp. 662-666. DOI
Li, N., Overkleeft, H.S., Florea, B. I , Activity-based protein profiling: an enabling technology in chemical biology research, Current Opinion in Chemical Biology, vol. 16, no. 1-2, pp. 227-233. DOI
van der Linden, W.A., Willems, L. I, Shabaneh, T.B., Li, N., Ruben, M., Florea, B. I, van der Marel, G.A., Kaiser, M., Kisselev, A.F., Overkleeft, H.S. , Discovery of a potent and highly beta 1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones, Organic & Biomolecular Chemistry, vol. 10, no. 1, pp. 181-194. DOI
Willems, L. I, Li, N., Florea, B. I, Ruben, M., van der Marel, G.A., Overkleeft, H.S. , Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities, Angewandte Chemie-International Edition, vol. 51, no. 18, pp. 4431-4434. DOI
Li, J., Girard, G., Florea, B. I, Geurink, P.P., Li, N., van der Marel, G.A., Overhand, M., Overkleeft, H.S., van Wezel, G.P. , Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach, Organic & Biomolecular Chemistry, vol. 10, no. 43, pp. 8677-8683.
Kallemeijn, W.W., Li, K.Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J.B., Willems, L. I, Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B. I, Codee, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12529-12533.
2011
Willems, L. I, Van der Linden, W.A., Li, N., Li, K.Y., Liu, N., Hoogendoorn, S., Van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling, Accounts of Chemical Research, vol. 44, no. 9, pp. 718-729.
Geurink, P.P., Florea, B. I, Overkleeft, H.S. , Activity-Based Profiling of 2-Oxoglutarate Oxygenases, Chemistry & Biology, vol. 18, no. 5, pp. 557-559. DOI
Mirabella, A.C., Pletnev, A.A., Downey, S.L., Florea, B. I, Shabaneh, T.B., Britton, M., Verdoes, M., Filippov, D.V., Overkleeft, H.S., Kisselev, A.F. , Specific Cell-Permeable Inhibitor of Proteasome Trypsin-like Sites Selectively Sensitizes Myeloma Cells to Bortezomib and Carfilzomib, Chemistry & Biology, vol. 18, no. 5, pp. 608-618. DOI
Hoogendoorn, S., Willems, L., Florea, B., Overkleeft, H. , Hypersensitive Response to Over-reactive Cysteines, Angew Chem Int Ed Engl, vol. 50, issue 24, pp. 5434-5436. DOI
Clerc, J., Li, N., Krahn, D., Groll, M., Bachmann, A.S., Florea, B. I, Overkleeft, H.S., Kaiser, M. , The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity, Chem Commun (Camb), vol. 47, no. 1, pp. 385-7. DOI
Chang, J.T., Ciocca, M.L., Kinjyo, I, Palanivel, V.R., McClurkin, C.E., Dejong, C.S., Mooney, E.C., Kim, J.S., Steinel, N.C., Oliaro, J., Yin, C.C., Florea, B. I, Overkleeft, H.S., Berg, L.J., Russell, S.M., Koretzky, G.A., Jordan, M.S., Reiner, S.L. , Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division, Immunity, vol. 34, no. 4, pp. 492-504. DOI
Hoogendoorn, S., Habets, K.L., Passemard, S., Kuiper, J., van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Targeted pH-dependent fluorescent activity-based cathepsin probes, Chemical Communications, vol. 47, no. 33, pp. 9363-9365. DOI
Geurink, P.P., Florea, B. I, Li, N., Witte, M.D., Verasdonck, J., Kuo, C.L., van der Marel, G.A., Overkleeft, H.S. , A levulinoyl ester based cleavable linker for activity-based protein profiling, Angewandte Chemie, International Edition, pp. in press.
2010
Geurink, P.P., Florea, B. I, Van der Marel, G.A., Kessler, B.M., Overkleeft, H.S. , Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates, Chemical Communications, vol. 46, pp. 9052-9054. DOI
Screen, M., Britton, M., Downey, S.L., Verdoes, M., Voges, M.J., Blom, A.E., Guerink, P.P., Risseeuw, M.D., Florea, B. I, van der Linden, W.A., Pletnev, A.A., Overkleeft, H.S., Kisselev, A.F. , The nature of pharmacophore influences active site specificity of proteasome inhibitors, J Biol Chem, vol. 285, pp. 40125-40134. DOI
Verdoes, M., Willems, L. I, van der Linden, W.A., Duivenvoorden, B.A., van der Marel, G.A., Florea, B. I, Kisselev, A.F., Overkleeft, H.S. , A panel of subunit-selective activity-based proteasome probes, Org Biomol Chem, vol. 8, pp. 2719-2727. DOI
Geurink, P.P., Liu, N., Spaans, M.P., Downey, S.L., van den Nieuwendijk, A., van der Marel, G.A., Kisselev, A.F., Florea, B. I, Overkleeft, H.S. , Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome's Chymotrypsin-like Sites, Journal of Medicinal Chemistry, vol. 53, no. 5, pp. 2319-2323. DOI
Risseeuw, M.D., Florea, B. I, van der Marel, G.A., Overkleeft, H.S., Overhand, M. , Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors, Bioorg Chem, vol. 38, pp. 202-209. DOI
van der Linden, W.A., Geurink, P.P., Oskam, C., van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Proteasome selectivity towards Michael acceptor containing oligopeptide-based inhibitors, Org Biomol Chem, vol. 8, no. 8, pp. 1885-93. DOI
Florea, B. I, Verdoes, M., Li, N., van der Linden, W.A., Geurink, P.P., van den Elst, H., Hofmann, T., de Ru, A., van Veelen, P.A., Tanaka, K., Sasaki, K., Murata, S., den Dulk, H., Brouwer, J., Ossendorp, F.A., Kisselev, A.F., Overkleeft, H.S. , Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t, Chemistry & Biology, vol. 17, pp. 795-801.
Willems, L. I, Verdoes, M., Florea, B. I, van der Marel, G.A., Overkleeft, H.S. , Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation, ChemBioChem, vol. 11, pp. 1769-1781.
Witte, M.D., Kallemeijn, W.W., Aten, J., Li, K.Y., Strijland, A., Donker-Koopman, W.E., van den Nieuwendijk, A., Bleijlevens, B., Kramer, G., Florea, B. I, Hooibrink, B., Hollak, C.E.M., Ottenhoff, R., Boot, R.G., van der Marel, G.A., Overkleeft, H.S., Aerts, J. , Ultrasensitive in situ visualization of active glucocerebrosidase molecules, Nature Chemical Biology, vol. 6, no. 12, pp. 907-913. DOI
2009
Witte, M.D., Florea, B. I, Verdoes, M., Adeyanju, O., Van der Marel, G.A., Overkleeft, H.S. , O-GlcNAc Peptide Epoxyketones Are Recognized by Mammalian Proteasomes, Journal of the American Chemical Society, vol. 131, no. 34, pp. 12064-+. DOI
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