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2014
Paniagua Soriano, G., De Bruin, G., Overkleeft, H.S., Florea, B. I , Toward Understanding Induction of Oxidative Stress and Apoptosis by Proteasome Inhibitors, Antioxidants & redox signaling. DOI
Wieber, S., Florea, B., Wagner, A., Overkleeft, H., Hecker, M., Drews, O. , Towards cell-specific targeting of proteasomes in cardiovascular cells, Acta Physiologica, vol. 210, pp. 194-194.
Li, H., van der Linden, W.A., Verdoes, M., Florea, B. I, McAllister, F.E., Govindaswamy, K., Elias, J.E., Bhanot, P., Overkleeft, H.S., Bogyo, M. , Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes, ACS chemical biology. DOI
Gubbens, J., Zhu, H., Girard, G., Song, L., Florea, B. I, Aston, P., Ichinose, K., Filippov, D.V., Choi, Y.H., Overkleeft, H.S., Challis, G.L., van Wezel, G.P. , Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products, Chemistry & Biology, vol. 21, no. 6, pp. 707-18. DOI
2013
Baggelaar, M.P., Janssen, F.J., van Esbroeck, A.C.M., den Dulk, H., Allara, M., Hoogendoorn, S., McGuire, R., Florea, B. I, Meeuwenoord, N., van den Elst, H., van der Marel, G.A., Brouwer, J., Di Marzo, V., Overkleeft, H.S., van der Stelt, M. , Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-alpha in Brain, Angewandte Chemie-International Edition, vol. 52, no. 46, pp. 12081-12085. DOI
Li, N., Kuo, C.L., Paniagua, G., van den Elst, H., Verdoes, M., Willems, L. I, van der Linden, W.A., Ruben, M., van Genderen, E., Gubbens, J., van Wezel, G.P., Overkleeft, H.S., Florea, B. I , Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS, Nature Protocols, vol. 8, no. 6, pp. 1155-68. DOI
Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B. I, van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F. , Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites, Journal of Medicinal Chemistry, vol. 56, no. 3, pp. 1262-1275. DOI
Baggelaar, M.P., Janssen, F.J., van Esbroeck, A., den Dulk, H., Allarà, M., Hoogendoorn, S., McGuire, R., Florea, B. I, Meeuwenoord, N., van den Elst, H. , Inside Back Cover: Development of an Activity‐Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase‐α in Brain (Angew. Chem. Int. Ed. 46/2013), Angewandte Chemie International Edition, vol. 52, no. 46, pp. 12193-12193.
2012
Vermeij, W.P., Florea, B. I, Isenia, S., Alia, A., Brouwer, J., Backendorf, C. , Proteomic Identification of in Vivo Interactors Reveals Novel Function of Skin Cornification Proteins, Journal of Proteome Research, vol. 11, no. 6, pp. 3068-3076.
van der Linden, W.A., Li, N., Hoogendoorn, S., Ruben, M., Verdoes, M., Guo, J., Boons, G., van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: A comparative study, Bioorganic & Medicinal Chemistry, vol. 20, no. 2, pp. 662-666. DOI
Lanz, H.L., Florea, B. I, Noteborn, M.H.M., Backendorf, C. , Development and application of an in vitro apoptin kinase assay, Analytical Biochemistry, vol. 421, no. 1, pp. 68-74.
Brouwer, A.J., Jonker, A., Werkhoven, P., Kuo, E., Li, N., Gallastegui, N., Kernmink, J., Florea, B. I, Groll, M., Overkleeft, H.S., Liskamp, R.M.J. , Peptido Sulfonyl Fluorides as New Powerful Proteasome Inhibitors, Journal of Medicinal Chemistry, vol. 55, no. 24, pp. 10995-11003. DOI
Stolze, S.C., Deu, E., Kaschani, F., Li, N., Florea, B. I, Richau, K.H., Colby, T., van der Hoom, R.A.L., Overkleeft, H.S., Bogyo, M., Kaiser, M. , The Antimalarial Natural Product Symplostatin 4 Is a Nanomolar Inhibitor of the Food Vacuole Falcipains, Chemistry & Biology, vol. 19, no. 12, pp. 1546-1555. DOI
Li, N., Overkleeft, H.S., Florea, B. I , Activity-based protein profiling: an enabling technology in chemical biology research, Current Opinion in Chemical Biology, vol. 16, no. 1-2, pp. 227-233. DOI
van der Linden, W.A., Willems, L. I, Shabaneh, T.B., Li, N., Ruben, M., Florea, B. I, van der Marel, G.A., Kaiser, M., Kisselev, A.F., Overkleeft, H.S. , Discovery of a potent and highly beta 1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones, Organic & Biomolecular Chemistry, vol. 10, no. 1, pp. 181-194. DOI
Willems, L. I, Li, N., Florea, B. I, Ruben, M., van der Marel, G.A., Overkleeft, H.S. , Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities, Angewandte Chemie-International Edition, vol. 51, no. 18, pp. 4431-4434. DOI
Li, J., Girard, G., Florea, B. I, Geurink, P.P., Li, N., van der Marel, G.A., Overhand, M., Overkleeft, H.S., van Wezel, G.P. , Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach, Organic & Biomolecular Chemistry, vol. 10, no. 43, pp. 8677-8683.
Kallemeijn, W.W., Li, K.Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J.B., Willems, L. I, Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B. I, Codee, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12529-12533.
2011
Willems, L. I, Van der Linden, W.A., Li, N., Li, K.Y., Liu, N., Hoogendoorn, S., Van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling, Accounts of Chemical Research, vol. 44, no. 9, pp. 718-729.
Geurink, P.P., Florea, B. I, Overkleeft, H.S. , Activity-Based Profiling of 2-Oxoglutarate Oxygenases, Chemistry & Biology, vol. 18, no. 5, pp. 557-559. DOI
Mirabella, A.C., Pletnev, A.A., Downey, S.L., Florea, B. I, Shabaneh, T.B., Britton, M., Verdoes, M., Filippov, D.V., Overkleeft, H.S., Kisselev, A.F. , Specific Cell-Permeable Inhibitor of Proteasome Trypsin-like Sites Selectively Sensitizes Myeloma Cells to Bortezomib and Carfilzomib, Chemistry & Biology, vol. 18, no. 5, pp. 608-618. DOI
Hoogendoorn, S., Willems, L., Florea, B., Overkleeft, H. , Hypersensitive Response to Over-reactive Cysteines, Angew Chem Int Ed Engl, vol. 50, issue 24, pp. 5434-5436. DOI
Clerc, J., Li, N., Krahn, D., Groll, M., Bachmann, A.S., Florea, B. I, Overkleeft, H.S., Kaiser, M. , The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity, Chem Commun (Camb), vol. 47, no. 1, pp. 385-7. DOI
Chang, J.T., Ciocca, M.L., Kinjyo, I, Palanivel, V.R., McClurkin, C.E., Dejong, C.S., Mooney, E.C., Kim, J.S., Steinel, N.C., Oliaro, J., Yin, C.C., Florea, B. I, Overkleeft, H.S., Berg, L.J., Russell, S.M., Koretzky, G.A., Jordan, M.S., Reiner, S.L. , Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division, Immunity, vol. 34, no. 4, pp. 492-504. DOI
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