All journal publications (1963-2013)

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2013
Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B. I, van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F. , Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites, Journal of Medicinal Chemistry, vol. 56, no. 3, pp. 1262-1275. DOI
2012
Vermeij, W.P., Florea, B. I, Isenia, S., Alia, A., Brouwer, J., Backendorf, C. , Proteomic Identification of in Vivo Interactors Reveals Novel Function of Skin Cornification Proteins, Journal of Proteome Research, vol. 11, no. 6, pp. 3068-3076.
van der Linden, W.A., Li, N., Hoogendoorn, S., Ruben, M., Verdoes, M., Guo, J., Boons, G., van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: A comparative study, Bioorganic & Medicinal Chemistry, vol. 20, no. 2, pp. 662-666. DOI
Lanz, H.L., Florea, B. I, Noteborn, M.H.M., Backendorf, C. , Development and application of an in vitro apoptin kinase assay, Analytical Biochemistry, vol. 421, no. 1, pp. 68-74.
Brouwer, A.J., Jonker, A., Werkhoven, P., Kuo, E., Li, N., Gallastegui, N., Kernmink, J., Florea, B. I, Groll, M., Overkleeft, H.S., Liskamp, R.M.J. , Peptido Sulfonyl Fluorides as New Powerful Proteasome Inhibitors, Journal of Medicinal Chemistry, vol. 55, no. 24, pp. 10995-11003. DOI
Stolze, S.C., Deu, E., Kaschani, F., Li, N., Florea, B. I, Richau, K.H., Colby, T., van der Hoom, R.A.L., Overkleeft, H.S., Bogyo, M., Kaiser, M. , The Antimalarial Natural Product Symplostatin 4 Is a Nanomolar Inhibitor of the Food Vacuole Falcipains, Chemistry & Biology, vol. 19, no. 12, pp. 1546-1555. DOI
Li, N., Overkleeft, H.S., Florea, B. I , Activity-based protein profiling: an enabling technology in chemical biology research, Current Opinion in Chemical Biology, vol. 16, no. 1-2, pp. 227-233. DOI
van der Linden, W.A., Willems, L. I, Shabaneh, T.B., Li, N., Ruben, M., Florea, B. I, van der Marel, G.A., Kaiser, M., Kisselev, A.F., Overkleeft, H.S. , Discovery of a potent and highly beta 1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones, Organic & Biomolecular Chemistry, vol. 10, no. 1, pp. 181-194. DOI
Willems, L. I, Li, N., Florea, B. I, Ruben, M., van der Marel, G.A., Overkleeft, H.S. , Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities, Angewandte Chemie-International Edition, vol. 51, no. 18, pp. 4431-4434. DOI
Li, J., Girard, G., Florea, B. I, Geurink, P.P., Li, N., van der Marel, G.A., Overhand, M., Overkleeft, H.S., van Wezel, G.P. , Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach, Organic & Biomolecular Chemistry, vol. 10, no. 43, pp. 8677-8683.
Kallemeijn, W.W., Li, K.Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J.B., Willems, L. I, Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B. I, Codee, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12529-12533.
2011
Willems, L. I, Van der Linden, W.A., Li, N., Li, K.Y., Liu, N., Hoogendoorn, S., Van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling, Accounts of Chemical Research, vol. 44, no. 9, pp. 718-729.
Geurink, P.P., Florea, B. I, Overkleeft, H.S. , Activity-Based Profiling of 2-Oxoglutarate Oxygenases, Chemistry & Biology, vol. 18, no. 5, pp. 557-559. DOI
Mirabella, A.C., Pletnev, A.A., Downey, S.L., Florea, B. I, Shabaneh, T.B., Britton, M., Verdoes, M., Filippov, D.V., Overkleeft, H.S., Kisselev, A.F. , Specific Cell-Permeable Inhibitor of Proteasome Trypsin-like Sites Selectively Sensitizes Myeloma Cells to Bortezomib and Carfilzomib, Chemistry & Biology, vol. 18, no. 5, pp. 608-618. DOI
Hoogendoorn, S., Willems, L., Florea, B., Overkleeft, H. , Hypersensitive Response to Over-reactive Cysteines, Angew Chem Int Ed Engl, vol. 50, issue 24, pp. 5434-5436. DOI
Clerc, J., Li, N., Krahn, D., Groll, M., Bachmann, A.S., Florea, B. I, Overkleeft, H.S., Kaiser, M. , The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity, Chem Commun (Camb), vol. 47, no. 1, pp. 385-7. DOI
Chang, J.T., Ciocca, M.L., Kinjyo, I, Palanivel, V.R., McClurkin, C.E., Dejong, C.S., Mooney, E.C., Kim, J.S., Steinel, N.C., Oliaro, J., Yin, C.C., Florea, B. I, Overkleeft, H.S., Berg, L.J., Russell, S.M., Koretzky, G.A., Jordan, M.S., Reiner, S.L. , Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division, Immunity, vol. 34, no. 4, pp. 492-504. DOI
Hoogendoorn, S., Habets, K.L., Passemard, S., Kuiper, J., van der Marel, G.A., Florea, B. I, Overkleeft, H.S. , Targeted pH-dependent fluorescent activity-based cathepsin probes, Chemical Communications, vol. 47, no. 33, pp. 9363-9365. DOI
Geurink, P.P., Florea, B. I, Li, N., Witte, M.D., Verasdonck, J., Kuo, C.L., van der Marel, G.A., Overkleeft, H.S. , A levulinoyl ester based cleavable linker for activity-based protein profiling, Angewandte Chemie, International Edition, pp. in press.
2010
Geurink, P.P., Florea, B. I, Van der Marel, G.A., Kessler, B.M., Overkleeft, H.S. , Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates, Chemical Communications, vol. 46, pp. 9052-9054. DOI
Screen, M., Britton, M., Downey, S.L., Verdoes, M., Voges, M.J., Blom, A.E., Guerink, P.P., Risseeuw, M.D., Florea, B. I, van der Linden, W.A., Pletnev, A.A., Overkleeft, H.S., Kisselev, A.F. , The nature of pharmacophore influences active site specificity of proteasome inhibitors, J Biol Chem, vol. 285, pp. 40125-40134. DOI
Semrau, S., Monster, M.W.L., van der Knaap, M., Florea, B. I, Schmidt, T., Overhand, M. , Membrane lysis by gramicidin S visualized in red blood cells and giant vesicles, Biochimica Et Biophysica Acta-Biomembranes, vol. 1798, no. 11, pp. 2033-2039. DOI
Verdoes, M., Willems, L. I, van der Linden, W.A., Duivenvoorden, B.A., van der Marel, G.A., Florea, B. I, Kisselev, A.F., Overkleeft, H.S. , A panel of subunit-selective activity-based proteasome probes, Org Biomol Chem, vol. 8, pp. 2719-2727. DOI
Geurink, P.P., Liu, N., Spaans, M.P., Downey, S.L., van den Nieuwendijk, A., van der Marel, G.A., Kisselev, A.F., Florea, B. I, Overkleeft, H.S. , Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome's Chymotrypsin-like Sites, Journal of Medicinal Chemistry, vol. 53, no. 5, pp. 2319-2323. DOI
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