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de Bruin, G., Huber, E.M., Xin, B.T., van Rooden, E.J., Al-Ayed, K., Kim, K.B., Kisselev, A.F., Driessen, C., van der Stelt, M., van der Marel, G.A., Groll, M., Overkleeft, H.S. , Structure-Based Design of beta1i or beta5i Specific Inhibitors of Human Immunoproteasomes, Journal of Medicinal Chemistry, vol. 57, no. 14, pp. 6197-209. DOI
Geurink, P.P., van der Linden, W.A., Mirabella, A.C., Gallastegui, N., de Bruin, G., Blom, A.E.M., Voges, M.J., Mock, E.D., Florea, B. I, van der Marel, G.A., Driessen, C., van der Stelt, M., Groll, M., Overkleeft, H.S., Kisselev, A.F. , Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites, Journal of Medicinal Chemistry, vol. 56, no. 3, pp. 1262-1275. DOI
Kraus, M., Bader, J., Hess, D., Haile, S., Overkleeft, H., Driessen, C., Sakk, , The HIV protease inhibitor Nelfinavir has proteasome-inhibiting activity in vivo distinct from Bortezomib, Onkologie, vol. 34, pp. 159-159.
Clerc, J., Florea, B. I, Kraus, M., Groll, M., Huber, R., Bachmann, A.S., Dudler, R., Driessen, C., Overkleeft, H.S., Kaiser, M. , Syringolin A Selectively Labels the 20 S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines, Chembiochem, vol. 10, no. 16, pp. 2638-2643. DOI
Ruckrich, T., Kraus, M., Gogel, J., Beck, A., Ovaa, H., Verdoes, M., Overkleeft, H.S., Kalbacher, H., Driessen, C. , Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells, Leukemia, vol. 23, no. 6, pp. 1098-1105. DOI
Hillaert, U., Verdoes, M., Florea, B. I, Saragliadis, A., Habets, K.L., Kuiper, J., Van Calenbergh, S., Ossendorp, F., van der Marel, G.A., Driessen, C., Overkleeft, H.S. , Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells, Angew Chem Int Ed Engl. DOI
Fissolo, N., Kraus, M., Reich, M., Ayturan, M., Overkleeft, H., Driessen, C., Weissert, R. , Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation, European Journal of Immunology, vol. 38, no. 9, pp. 2401-2411. DOI
Kessler, T., Reich, M., Jahn, G., Tolosa, E., Beck, A., Kalbacher, H., Overkleeft, H., Schempp, S., Driessen, C. , Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels, Journal of General Virology, vol. 89, pp. 2427-2436. DOI
Kraus, M., Malenke, E., Gogel, J., Muller, H., Ruckrich, T., Overkleeft, H., Ovaa, H., Koscielniak, E., Hartmann, J.T., Driessen, C. , Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis, Molecular Cancer Therapeutics, vol. 7, no. 7, pp. 1940-1948. DOI
Burster, T., Beck, A., Poeschel, S., Oren, A., Baechle, D., Reich, M., Roetzschke, O., Falk, K., Boehm, B.O., Youssef, S., Kalbacher, H., Overkleeft, H., Tolosa, E., Driessen, C. , Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro, Immunology, vol. 121, no. 1, pp. 82-93. DOI
Kraus, M., Ruckrich, T., Reich, M., Gogel, J., Beck, A., Kammer, W., Berkers, C.R., Burg, D., Overkleeft, H., Ovaa, H., Driessen, C. , Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells, Leukemia, vol. 21, no. 1, pp. 84-92.
Reich, M., van Swieten, P.F., Sommandas, V., Kraus, M., Fischer, R., Weber, E., Kalbacher, H., Overkleeft, H.S., Driessen, C. , Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cellpenetrating peptides mediate nonselective transport to cysteine cathepsins, Journal of Leukocyte Biology, vol. 81, no. 4, pp. 990-1001. DOI
Burster, T., Beck, A., Tolosa, E., Schnorrer, P., Weissert, R., Reich, M., Kraus, M., Kalbacher, H., Haring, H.U., Weber, E., Overkleeft, H., Driessen, C. , Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells, Journal of Immunology, vol. 175, no. 9, pp. 5940-5949.
van Zutphen, S., Kraus, M., Driessen, C., van der Marel, G.A., Overkleeft, H.S., Reedijk, J. , Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity, Journal of Inorganic Biochemistry, vol. 99, no. 6, pp. 1384-1389.
Lautwein, A., Kraus, M., Reich, M., Burster, T., Brandenburg, J., Overkleeft, H.S., Schwarz, G., Kammer, W., Weber, E., Kalbacher, H., Nordheim, A., Driessen, C. , Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner, Journal of Leukocyte Biology, vol. 75, no. 5, pp. 844-855.
van Swieten, P.F., Maehr, R., van den Nieuwendijk, A.M.C.H., Kessler, B.M., Reich, M., Wong, C.S., Kalbacher, H., Leeuwenburgh, M.A., Driessen, C., van der Marel, G.A., Ploegh, H.L., Overkleeft, H.S. , Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases, Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 12, pp. 3131-3134.
Wiendl, H., Lautwein, A., Mitsdorffer, M., Krause, S., Erfurth, S., Wienhold, W., Morgalla, M., Weber, E., Overkleeft, H.S., Lochmuller, H., Melms, A., Tolosa, E., Driessen, C. , Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies, Journal of Neuroimmunology, vol. 138, no. 1-2, pp. 132-143.
Greiner, A., Lautwein, A., Overkleeft, H.S., Weber, E., Driessen, C. , Activity and subcellular distribution of cathepsins in primary human monocytes, Journal of Leukocyte Biology, vol. 73, no. 2, pp. 235-242.
Lautwein, A., Burster, T., Lennon-Dumenil, A.M., Overkleeft, H.S., Weber, E., Kalbacher, H., Driessen, C. , Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells, European Journal of Immunology, vol. 32, no. 12, pp. 3348-3357.
Lennon-Dumenil, A.M., Roberts, R.A., Valentijn, K., Driessen, C., Overkleeft, H.S., Erickson, A., Peters, P.J., Bikoff, E., Ploegh, H.L., Bryant, P.W. , The p41 isoform of invariant chain is a chaperone for cathepsin L, Embo Journal, vol. 20, no. 15, pp. 4055-4064.