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2012
van den Nieuwendijk, A.M.C.H., van den Berg, R.J.B.H.N., Ruben, M., Witte, M.D., Brussee, J., Boot, R.G., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Synthesis of Eight 1-Deoxynojirimycin Isomers from a Single Chiral Cyanohydrin, European Journal of Organic Chemistry, no. 18, pp. 3437-3446. DOI
Kallemeijn, W.W., Li, K.Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J.B., Willems, L. I, Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B. I, Codee, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12529-12533.
2011
Dekker, N., van Dussen, L., Hollak, C.E.M., Overkleeft, H., Scheij, S., Ghauharali, K., van Breemen, M.J., Ferraz, M.J., Groener, J.E.M., Maas, M., Wijburg, F.A., Speijer, D., Tylki-Szymanska, A., Mistry, P.K., Boot, R.G., Aerts, J.M. , Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response, Blood, vol. 118, no. 16, pp. E118-E127.
Witte, M.D., Walvoort, M.T., Li, K.Y., Kallemeijn, W.W., Donker-Koopman, W.E., Boot, R.G., Aerts, J.M., Codee, J.D., van der Marel, G.A., Overkleeft, H.S. , Activity-Based Profiling of Retaining beta-Glucosidases: A Comparative Study, Chembiochem, vol. 12, no. 8, pp. 1263-9. DOI
Aerts, J.M., Kallemeijn, W.W., Wegdam, W., Joao Ferraz, M., van Breemen, M.J., Dekker, N., Kramer, G., Poorthuis, B.J., Groener, J.E., Cox-Brinkman, J., Rombach, S.M., Hollak, C.E., Linthorst, G.E., Witte, M.D., Gold, H., van der Marel, G.A., Overkleeft, H.S., Boot, R.G. , Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies, J Inherit Metab Dis, vol. 34, issue 3, pp. 99-119. DOI
Gold, H., Boot, R.G., Aerts, J.M.F.G., Overkleeft, H.S., Codee, J.D.C., van der Marel, G.A. , A Concise Synthesis of Globotriaosylsphingosine, European Journal of Organic Chemistry, no. 9, pp. 1652-1663.
Aerts, J.M.F.G., Kallemeijn, W.W., Wegdam, W., Ferraz, M.J., van Breemen, M.J., Dekker, N., Kramer, G., Poorthuis, B.J., Groener, J.E.M., Cox-Brinkman, J., Rombach, S.M., Hollak, C.E.M., Linthorst, G.E., Witte, M.D., Gold, H., van der Marel, G.A., Overkleeft, H.S., Boot, R.G. , Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies, Journal of Inherited Metabolic Disease, vol. 34, no. 3, pp. 605-619. DOI
van den Berg, R.J.B.H.N., Wennekes, T., Ghisaidoobe, A., Donker-Koopman, W.E., Strijland, A., Boot, R.G., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors, Acs Medicinal Chemistry Letters, vol. 2, no. 7, pp. 519-522. DOI
Dekker, N., Voorn-Brouwer, T., Verhoek, M., Wennekes, T., Narayan, R.S., Speijer, D., Hollak, C.E., Overkleeft, H.S., Boot, R.G., Aerts, J.M. , The cytosolic beta-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation, Blood Cells Mol Dis, vol. 46, no. 1, pp. 19-26. DOI
Aerts, J.M., Boot, R.G., van Eijk, M., Groener, J., Bijl, N., Lombardo, E., Bietrix, F.M., Dekker, N., Groen, A.K., Ottenhoff, R., van Roomen, C., Aten, J., Serlie, M., Langeveld, M., Wennekes, T., Overkleeft, H.S. , Glycosphingolipids and Insulin Resistance, Sphingolipids and Metabolic Disease, vol. 721, pp. 99-119.
Ghisaidoobe, A., Bikker, P., de Bruijn, A.C.J., Godschalk, F.D., Rogaar, E., Guijt, M.C., Hagens, P., Halma, J.M., van't Hart, S.M., Luitjens, S.B., van Rixel, V.H.S., Wijzenbroek, M., Zweegers, T., Donker-Koopman, W.E., Strijland, A., Boot, R., van der Marel, G., Overkleeft, H.S., Aerts, J., van den Berg, R. , Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars, Acs Medicinal Chemistry Letters, vol. 2, no. 2, pp. 119-123. DOI
2010
Dinkelaar, J., Duivenvoorden, B.A., Wennekes, T., Overkleeft, H.S., Boot, R.G., Aerts, J., Codee, J.D.C., van der Marel, G.A. , A Preparative Synthesis of Human Chitinase Fluorogenic Substrate (4'-Deoxychitobiosyl)-4-methylumbelliferone, European Journal of Organic Chemistry, no. 13, pp. 2565-2570. DOI
Wennekes, T., Meijer, A.J., Groen, A.K., Boot, R.G., Groener, J.E., van Eijk, M., Ottenhoff, R., Bijl, N., Ghauharali, K., Song, H., O'Shea, T.J., Liu, H.L., Yew, N., Copeland, D., van den Berg, R.J., van der Marel, G.A., Overkleeft, H.S., Aerts, J.M. , Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation, Journal of Medicinal Chemistry, vol. 53, no. 2, pp. 689-698. DOI
van den Nieuwendijk, A.M.C.H., Ruben, M., Engelsma, S.E., Risseeuw, M.D.P., van den Berg, R.J.B.H.N., Boot, R.G., Aerts, J.M., Brussee, J., van der Marel, G.A., Overkleeft, H.S. , Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin, Organic Letters, vol. 12, pp. 3957-3959.
Witte, M.D., Kallemeijn, W.W., Aten, J., Li, K.Y., Strijland, A., Donker-Koopman, W.E., van den Nieuwendijk, A., Bleijlevens, B., Kramer, G., Florea, B. I, Hooibrink, B., Hollak, C.E.M., Ottenhoff, R., Boot, R.G., van der Marel, G.A., Overkleeft, H.S., Aerts, J. , Ultrasensitive in situ visualization of active glucocerebrosidase molecules, Nature Chemical Biology, vol. 6, no. 12, pp. 907-913. DOI
2009
Wennekes, T., van den Berg, R., Boot, R.G., van der Marel, G.A., Overkleeft, H.S., Aerts, J. , Glycosphingolipids-Nature, Function, and Pharmacological Modulation, Angewandte Chemie-International Edition, vol. 48, no. 47, pp. 8848-8869. DOI
2007
Bussink, A.P., van Swieten, P.F., Ghauharali, K., Scheij, S., van Eijk, M., Wennekes, T., van der Marel, G.A., Boot, R.G., Aerts, J.M.F.G., Overkleeft, H.S. , N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides, Journal of Lipid Research, vol. 48, no. 6, pp. 1417-1421. DOI
Boot, R.G., Verhoek, M., Donker-Koopman, W., Strijland, A., van Marle, J., Overkleeft, H.S., Wennekes, T., Aerts, J.M.F.G. , Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2, Journal of Biological Chemistry, vol. 282, no. 2, pp. 1305-1312. DOI
2003
Aguilera, B., der Ghauharali-van Vlugt, K., Helmond, M.T.J., Out, J.M.M., Donker-Koopman, W.E., Groener, J.E.M., Boot, R.G., Renkema, G.H., van der Marel, G.A., van Boom, J.H., Overkleeft, H.S., Aerts, J.M.F.G. , Transglycosidase activity of chitotriosidase - Improved enzymatic assay for the human macrophage chitinase, Journal of Biological Chemistry, vol. 278, no. 42, pp. 40911-40916.