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A
Aerts, J.M., Kallemeijn, W.W., Wegdam, W., Joao Ferraz, M., van Breemen, M.J., Dekker, N., Kramer, G., Poorthuis, B.J., Groener, J.E., Cox-Brinkman, J., Rombach, S.M., Hollak, C.E., Linthorst, G.E., Witte, M.D., Gold, H., van der Marel, G.A., Overkleeft, H.S., Boot, R.G. , Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies, J Inherit Metab Dis, vol. 34, issue 3, pp. 99-119. DOI
Aerts, J.M.F.G., Kallemeijn, W.W., Wegdam, W., Ferraz, M.J., van Breemen, M.J., Dekker, N., Kramer, G., Poorthuis, B.J., Groener, J.E.M., Cox-Brinkman, J., Rombach, S.M., Hollak, C.E.M., Linthorst, G.E., Witte, M.D., Gold, H., van der Marel, G.A., Overkleeft, H.S., Boot, R.G. , Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies, Journal of Inherited Metabolic Disease, vol. 34, no. 3, pp. 605-619. DOI
Aerts, J.M., Boot, R.G., van Eijk, M., Groener, J., Bijl, N., Lombardo, E., Bietrix, F.M., Dekker, N., Groen, A.K., Ottenhoff, R., van Roomen, C., Aten, J., Serlie, M., Langeveld, M., Wennekes, T., Overkleeft, H.S. , Glycosphingolipids and Insulin Resistance, Sphingolipids and Metabolic Disease, vol. 721, pp. 99-119.
Aerts, J.M., Ottenhoff, R., Powlson, A.S., Grefhorst, A., van Eijk, M., Dubbelhuis, P.F., Aten, J., Kuipers, F., Serlie, M.J., Wennekes, T., Sethi, J.K., O'Rahilly, S., Overkleeft, H.S. , Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity, Diabetes, vol. 56, no. 5, pp. 1341-1349.
Aguilera, B., der Ghauharali-van Vlugt, K., Helmond, M.T.J., Out, J.M.M., Donker-Koopman, W.E., Groener, J.E.M., Boot, R.G., Renkema, G.H., van der Marel, G.A., van Boom, J.H., Overkleeft, H.S., Aerts, J.M.F.G. , Transglycosidase activity of chitotriosidase - Improved enzymatic assay for the human macrophage chitinase, Journal of Biological Chemistry, vol. 278, no. 42, pp. 40911-40916.
B
Boot, R.G., Verhoek, M., Donker-Koopman, W., Strijland, A., van Marle, J., Overkleeft, H.S., Wennekes, T., Aerts, J.M.F.G. , Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2, Journal of Biological Chemistry, vol. 282, no. 2, pp. 1305-1312. DOI
Bussink, A.P., van Swieten, P.F., Ghauharali, K., Scheij, S., van Eijk, M., Wennekes, T., van der Marel, G.A., Boot, R.G., Aerts, J.M.F.G., Overkleeft, H.S. , N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides, Journal of Lipid Research, vol. 48, no. 6, pp. 1417-1421. DOI
D
Dekker, N., Voorn-Brouwer, T., Verhoek, M., Wennekes, T., Narayan, R.S., Speijer, D., Hollak, C.E., Overkleeft, H.S., Boot, R.G., Aerts, J.M. , The cytosolic beta-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation, Blood Cells Mol Dis, vol. 46, no. 1, pp. 19-26. DOI
Dekker, N., van Dussen, L., Hollak, C.E.M., Overkleeft, H., Scheij, S., Ghauharali, K., van Breemen, M.J., Ferraz, M.J., Groener, J.E.M., Maas, M., Wijburg, F.A., Speijer, D., Tylki-Szymanska, A., Mistry, P.K., Boot, R.G., Aerts, J.M. , Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response, Blood, vol. 118, no. 16, pp. E118-E127.
Dinkelaar, J., Duivenvoorden, B.A., Wennekes, T., Overkleeft, H.S., Boot, R.G., Aerts, J., Codee, J.D.C., van der Marel, G.A. , A Preparative Synthesis of Human Chitinase Fluorogenic Substrate (4'-Deoxychitobiosyl)-4-methylumbelliferone, European Journal of Organic Chemistry, no. 13, pp. 2565-2570. DOI
G
Gold, H., Mirzaian, M., Dekker, N., Ferraz, M.J., Lugtenburg, J., Codee, J.D.C., van der Marel, G.A., Overkleeft, H.S., Linthorst, G.E., Groener, J.E.M., Aerts, J.M., Poorthuis, B.J.H.M. , Quantification of Globotriaosylsphingosine in Plasma and Urine of Fabry Patients by Stable Isotope Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry, Clinical Chemistry, vol. 59, no. 3, pp. 547-556. DOI
Gold, H., Mirzaian, M., Dekker, N., Joao Ferraz, M., Lugtenburg, J., Codee, J.D., van der Marel, G.A., Overkleeft, H.S., Linthorst, G.E., Groener, J.E., Aerts, J.M., Poorthuis, B.J. , Quantification of Globotriaosylsphingosine in Plasma and Urine of Fabry Patients by Stable Isotope Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry, Clinical chemistry. DOI
Ghisaidoobe, A., Bikker, P., de Bruijn, A.C.J., Godschalk, F.D., Rogaar, E., Guijt, M.C., Hagens, P., Halma, J.M., van't Hart, S.M., Luitjens, S.B., van Rixel, V.H.S., Wijzenbroek, M., Zweegers, T., Donker-Koopman, W.E., Strijland, A., Boot, R., van der Marel, G., Overkleeft, H.S., Aerts, J., van den Berg, R. , Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars, Acs Medicinal Chemistry Letters, vol. 2, no. 2, pp. 119-123. DOI
Gold, H., Munneke, S., Dinkelaar, J., Overkleeft, H.S., Aerts, J.M., Codee, J.D., van der Marel, G.A. , A practical synthesis of capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates, Carbohydrate Research, vol. 346, issue 12, pp. 1467-1478. DOI
Gold, H., Boot, R.G., Aerts, J.M.F.G., Overkleeft, H.S., Codee, J.D.C., van der Marel, G.A. , A Concise Synthesis of Globotriaosylsphingosine, European Journal of Organic Chemistry, no. 9, pp. 1652-1663.
K
Kallemeijn, W.W., Li, K.Y., Witte, M.D., Marques, A.R.A., Aten, J., Scheij, S., Jiang, J.B., Willems, L. I, Voorn-Brouwer, T.M., van Roomen, C.P.A.A., Ottenhoff, R., Boot, R.G., van den Elst, H., Walvoort, M.T.C., Florea, B. I, Codee, J.D.C., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo, Angewandte Chemie-International Edition, vol. 51, no. 50, pp. 12529-12533.
L
Lombardo, E., van Roomen, C.P.A.A., van Puijvelde, G.H., Ottenhoff, R., van Eijk, M., Aten, J., Kuiper, J., Overkleeft, H.S., Groen, A.K., Verhoeven, A.J., Aerts, J.M.F.G., Bietrix, F. , Correction of Liver Steatosis by a Hydrophobic Iminosugar Modulating Glycosphingolipids Metabolism, Plos One, vol. 7, no. 10.
O
Overkleeft, H.S., Renkema, G.H., Neele, J., Vianello, P., Hung, I.O., Strijland, A., van der Burg, A.M., Koomen, G.J., Pandit, U.K., Aerts, J.M.F.G. , Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase, Journal of Biological Chemistry, vol. 273, no. 41, pp. 26522-26527.
R
Risseeuw, M.D.P., van den Berg, R., Donker-Koopman, W.E., van der Marel, G.A., Aerts, J., Overhand, M., Overkleeft, H.S. , Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors, Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 23, pp. 6600-6603. DOI
S
Smid, B.E., Rombach, S.M., Aerts, J.M.F.G., Kuiper, S., Mirzaian, M., Overkleeft, H.S., Poorthuis, B.J.H.M., Hollak, C.E.M., Groener, J.E.M., Linthorst, G.E. , Consequences of a global enzyme shortage of agalsidase beta in adult Dutch Fabry patients, Orphanet Journal of Rare Diseases, vol. 6.
V
Vrins, C.L.J., Bietrix, F., Lombardo, E., van Roomen, C.P.P.A., Ottenhoff, R., Overkleeft, H.S., Aerts, J.M. , Glycosphingolipid synthesis inhibitor AMP-DNM lowers plasma cholesterol levels by promoting fecal cholesterol excretion without inhibiting cholesterol absorption, Clinical Lipidology, vol. 7, no. 2, pp. 241-248. DOI
van den Nieuwendijk, A.M.C.H., van den Berg, R.J.B.H.N., Ruben, M., Witte, M.D., Brussee, J., Boot, R.G., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Synthesis of Eight 1-Deoxynojirimycin Isomers from a Single Chiral Cyanohydrin, European Journal of Organic Chemistry, no. 18, pp. 3437-3446. DOI
van den Berg, R.J.B.H.N., Wennekes, T., Ghisaidoobe, A., Donker-Koopman, W.E., Strijland, A., Boot, R.G., van der Marel, G.A., Aerts, J.M.F.G., Overkleeft, H.S. , Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors, Acs Medicinal Chemistry Letters, vol. 2, no. 7, pp. 519-522. DOI
van Scherpenzeel, M., van den Berg, R., Donker-Koopman, W.E., Liskamp, R.M.J., Aerts, J., Overkleeft, H.S., Pieters, R.J. , Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase, Bioorganic & Medicinal Chemistry, vol. 18, no. 1, pp. 267-273. DOI
van den Nieuwendijk, A.M.C.H., Ruben, M., Engelsma, S.E., Risseeuw, M.D.P., van den Berg, R.J.B.H.N., Boot, R.G., Aerts, J.M., Brussee, J., van der Marel, G.A., Overkleeft, H.S. , Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin, Organic Letters, vol. 12, pp. 3957-3959.
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