A Novel-Approach Towards the Synthesis of Pyrophosphate Analogs of Farnesyl Pyrophosphate

Publication Type:

Journal Article

Source:

Recueil Des Travaux Chimiques Des Pays-Bas-Journal of the Royal Netherlands Chemical Society, Volume 113, Number 12, pp. 563-566 (1994)

ISBN:

0165-0513

Keywords:

phosphonophosphate; phosphonophosphonate; phosphonomorpholidate; inhibitor; squalene synthase; synthase; squalene

Abstract:

The synthesis of two new analogues (i.e. 3 and 4) of farnesyl pyrophosphate (FPP) containing a phosphonophosphate and a phosphonophosphonate moiety was accomplished via the phosphonomorpholidate. The latter was easily obtained by treatment of a phosphonic chloride with morpholine.

30/11/2007