Publication Type:Journal Article
Source:Recueil Des Travaux Chimiques Des Pays-Bas-Journal of the Royal Netherlands Chemical Society, Volume 113, Number 12, p.563-566 (1994)
Keywords:phosphonophosphate; phosphonophosphonate; phosphonomorpholidate; inhibitor; squalene synthase; synthase; squalene
The synthesis of two new analogues (i.e. 3 and 4) of farnesyl pyrophosphate (FPP) containing a phosphonophosphate and a phosphonophosphonate moiety was accomplished via the phosphonomorpholidate. The latter was easily obtained by treatment of a phosphonic chloride with morpholine.