A convenient automated solid-phase synthesis of PNA-(5')-DNA-(3')-PNA chimera

Publication Type:

Journal Article

Source:

Tetrahedron Letters, Volume 38, Number 13, pp. 2249-2252 (1997)

ISBN:

0040-4039

Keywords:

peptide nucleic-acids; DNA; pna; polyamide; backbone

Abstract:

An automated online solid-phase synthesis of Ac-cac ct T*GG TC t*ac ct-Gly-OH1 using standard DNA and appropriately protected PNA building blocks (2-5) is described. This chimera forms stable duplexes with complementary DNA and RNA. (C) 1997 Elsevier Science Ltd.

30/11/2007