Dmitri Filippov | Bio-organic Synthesis

Dmitri Filippov, Ph.D.

Position:

Assistant professor

Telephone number: +31 (0)71 527 4768
E-mail address: filippov@chem.leidenuniv.nl
Faculty/Unit: Faculty of Science, Leiden Institute of Chemistry, Bio-organic Synthesis
Office address: Gorlaeus Laboratories
Einsteinweg 55
2333 CC Leiden
roomnumber L148

Biography: Dmitri Filippov was born on November 21, 1966 in Moscow and studied chemistry at Moscow Institute of Fine Chemical Technology. After the graduation he learned the ABC’s of synthetic bioorganic chemistry under the supervision of Dr. B.I. Mitsner. In 1992 he moved to Leiden and after a short period was appointed as a Ph. D. student in the group of Prof. J.H. van Boom. Upon completion of his Ph.D. thesis ‘Phosphoramidites in synthetic bioorganic chemistry’ he remained in the BIOSYN group working on a wide range of research topics for the most part involving synthesis of modified biopolymers. Over the years of continuous synthetic activities he also managed to contribute to the fields of natural product synthesis, fluorous chemistry and protein synthesis. At present Dmitri Filippov holds a tenure-track position in Leiden.

2012

Virgen-Slane, R., Rozovics, J.M., Fitzgerald, K.D., Ngo, T., Chou, W., van Noort, G.J.V., Filippov, D.V., Gershon, P.D., Semler, B.L. , An RNA virus hijacks an incognito function of a DNA repair enzyme, Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 36, pp. 14634-14639.

Hogendorf, W.F.J., Kropec, A., Filippov, D.V., Overkleeft, H.S., Huebner, J., van der Marel, G.A., Codee, J.D.C. , Light fluorous synthesis of glucosylated glycerol teichoic acids, Carbohydrate Research, vol. 356, pp. 142-151. DOI

Hogendorf, W.F.J., Lameijer, L.N., Beenakker, T.J.M., Overkleeft, H.S., Filippov, D.V., Codee, J.D.C., Van der Marel, G.A. , Fluorous Linker Facilitated Synthesis of Teichoic Acid Fragments, Organic Letters, vol. 14, no. 3, pp. 848-851. DOI

Schein, C.H., Bowen, D.M., Lewis, J.A., Choi, K., Paul, A., van Noort, G.J.V., Lu, W.Z., Filippov, D.V. , Physicochemical property consensus sequences for functional analysis, design of multivalent antigens and targeted antivirals, Bmc Bioinformatics, vol. 13.

van der Heden Noort, G.J., Delft, P.v., Meeuwenoord, N.J., Overkleeft, H.S., van der Marel, G.A., Filippov, D.V. , Fully automated sequential solid phase approach towards viral RNA-nucleopeptides, Chemical communications, vol. 48, no. 65, pp. 8093-5.

van Noort, G.J.V., van Delft, P., Meeuwenoord, N.J., Overkleeft, H.S., van der Marel, G.A., Filippov, D.V. , Fully automated sequential solid phase approach towards viral RNA-nucleopeptides, Chemical Communications, vol. 48, no. 65, pp. 8093-8095.

Zom, G.G.P., Khan, S., Filippov, D.V., Ossendorp, F. , TLR Ligand-Peptide Conjugate Vaccines: Toward Clinical Application, Advances in Immunology , Vol 114: Synthetic Vaccines, vol. 114, pp. 177-201. DOI

2011

van Delft, P., van Schie, E., Meeuwenoord, N.J., Overkleeft, H.S., van der Marel, G.A., Filippov, D.V. , Oligonucleotide Conjugates by Means of Copper-Free Click Chemistry - Expanding the Repertoire of Strained Cyclooctyne Phosphoramidites, Synthesis-Stuttgart, no. 17, pp. 2724-2732. DOI

Mirabella, A.C., Pletnev, A.A., Downey, S.L., Florea, B. I, Shabaneh, T.B., Britton, M., Verdoes, M., Filippov, D.V., Overkleeft, H.S., Kisselev, A.F. , Specific Cell-Permeable Inhibitor of Proteasome Trypsin-like Sites Selectively Sensitizes Myeloma Cells to Bortezomib and Carfilzomib, Chemistry & Biology, vol. 18, no. 5, pp. 608-618. DOI

van der Heden Noort, G.J., Overkleeft, H.S., van der Marel, G.A., Filippov, D.V. , Ribosylation of Adenosine: An Orthogonally Protected Building Block for the Synthesis of ADP-Ribosyl Oligomers, Org Lett, vol. 13, issue 11, pp. 2920-2923. DOI

Hogendorf, W.F.J., Meeuwenoord, N., Overkleeft, H.S., Filippov, D.V., Laverde, D., Kropec, A., Huebner, J., Van der Marel, G.A., Codee, J.D.C. , Automated solid phase synthesis of teichoic acids, Chemical Communications, vol. 47, no. 31, pp. 8961-8963. DOI

2010

van den Boorn, J.G., Konijnenberg, D., Tjin, E.P.M., Picavet, D. I, Meeuwenoord, N.J., Filippov, D.V., van der Veen, J.P.W., Bos, J.D., Melief, C.J.M., Luiten, R.M. , Effective Melanoma Immunotherapy in Mice by the Skin-Depigmenting Agent Monobenzone and the Adjuvants Imiquimod and CpG, Plos One, vol. 5, no. 5. DOI

van der Heden Noort, G.J., Overkleeft, H.S., van der Marel, G.A., Filippov, D.V. , Synthesis of Nucleotidylated Poliovirus VPg Proteins, Journal of Organic Chemistry, vol. 75, no. 16, pp. 5733-5736. DOI

van der Heden Noort, G.J., van der Horst, M.G., Overkleeft, H.S., van der Marel, G.A., Filippov, D.V. , Synthesis of mono-ADP-ribosylated oligopeptides using ribosylated amino acid building blocks, J Am Chem Soc, vol. 132, no. 14, pp. 5236-40. DOI

Schein, C.H., Oezguen, N., van der Heden Noort, G.J., Filippov, D.V., Paul, A., Kumar, E., Braun, W. , NMR solution structur of poliovirus uridylyated peptide linked to the genome (VPgpU), Peptides, vol. 31, pp. 1441-1448. DOI

van Delft, P., Meeuwenoord, N.J., Hoogendoorn, S., Dinkelaar, J., Overkleeft, H.S., van der Marel, G.A., Filippov, D.V. , Synthesis of Oligoribonucleic Acid Conjugates Using a Cyclooctyne Phosphoramidite, Organic Letters, vol. 12, no. 23, pp. 5486-5489. DOI

2009

Ali, A., van den Berg, R., Overkleeft, H.S., Filippov, D.V., van der Marel, G.A., Codee, J.D.C. , Methylsulfonylethoxycarbonyl (Msc) and fluorous propylsulfonylethoxycarbonyl (FPsc) as hydroxy-protecting groups in carbohydrate chemistry, Tetrahedron Letters, vol. 50, no. 19, pp. 2185-2188. DOI

Khan, S., Weterings, J.J., Britten, C.M., de Jong, A.R., Graafland, D., Melief, C.J.M., van der Burg, S.H., van der Marel, G., Overkleeft, H.S., Filippov, D.V., Ossendorp, F. , Chirality of TLR-2 ligand Pam(3)CysSK(4) in fully synthetic peptide conjugates critically influences the induction of specific CD8(+) T-cells, Molecular Immunology, vol. 46, no. 6, pp. 1084-1091. DOI

Sepkhanova, I, Drescher, M., Meeuwenoord, N.J., Limpens, R.W.A.L., Koning, R. I, Filippov, D.V., Huber, M. , Monitoring Alzheimer Amyloid Peptide Aggregation by EPR , Applied Magnetic Resonance, vol. 36, no. 2-4, pp. 209-222. DOI

Hogendorf, W.F.J., Verhagen, C.P., Malta, E., Goosen, N., Overkleeft, H.S., Filippov, D.V., Van der Marel, G.A. , The synthesis of a menthol derivative of 2-aminopurine as a fluorescent DNA lesion, Tetrahedron, vol. 65, no. 50, pp. 10430-10435. DOI

Weterings, J.J., Khan, S., van der Heden Noort, G.J., Melief, C.J.M., Overkleeft, H.S., van der Burg, S.H., Ossendorp, F., van der Marel, G.A., Filippov, D.V. , 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation, Bioorganic & Medicinal Chemistry Letters, vol. 19, no. 8, pp. 2249-2251. DOI

van Montfoort, N., Camps, M.G., Khan, S., Filippov, D.V., Weterings, J.J., Griffith, J.M., Geuze, H.J., van Hall, T., Verbeek, J.S., Melief, C.J., Ossendorp, F. , Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity, Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 16, pp. 6730-6735. DOI

2008

Malta, E., Verhagen, C.P., Moolenaar, G.F., Filippov, D.V., van der Marel, G.A., Goosen, N. , Functions of base flipping in E. coli nucleotide excision repair, DNA Repair, vol. 7, no. 10, pp. 1647-1658. DOI

van der Heden Noort, G.J., Verhagen, C.P., van der Horst, M.G., Overkleeft, H.S., van der Marel, G.A., Filippov, D.V. , A Versatile One-Pot Procedure to Phosphate Monoesters and Pyrophosphates Using Di(p-methoxybenzyl)-N,N-diisopropylphosphoramidite, Organic Letters, vol. 10, no. 20, pp. 4461-4464. DOI

Ghisaidoobe, A.B.T., de Koning, M.C., Duynstee, H. I, Ten Kortenaar, P.B.W., Overkleeft, H.S., Filippov, D.V., van der Marel, G.A. , A two-step sulfurization for efficient solution-phase synthesis of phosphorothioate oligonucleotides, Tetrahedron Letters, vol. 49, no. 19, pp. 3129-3132. DOI

Dmitri Filippov teaches or supervises the following courses:

Dmitri currently supervises the following students:

06/07/2009

Bio-organic Synthesis

Dmitri Filippov, Ph.D.

Biography

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